In this eye-opening episode, Dr. Scott Sherr takes us deep into the fascinating world of GABAโyour brainโs primary calming neurotransmitter and the key to reducing stress, improving sleep, and enhancing focus. As a leading expert in health optimization and the founder of Troscriptionsยฎ, Dr. Sherr breaks down the science behind GABAโs crucial role in mental well-being, how lifestyle choices impact its function, and why most people are unknowingly depleting their GABA levels.
From the effects of alcohol on your brain to practical strategies like breathwork and nootropics, this conversation is packed with actionable insights to help you optimize your mind and body. If youโre looking to supercharge your cognitive health and unlock true mental clarity, this is an episode you donโt want to miss!
Looking for Peak Brain Performance? Try Troscriptionsยฎ!
For 10% off Just Blue, Blue Canatine, or TroCalm, go to https://troscriptions.com/ and use code PASSIONSTRUCK . In the UK: https://www.xbrain.co.uk/product/troscriptions-blue-cannatine
Want to learn the 12 philosophies that the most successful people use to create a limitless life? Order John R. Milesโs new book, Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life.
“A sense of purpose is fundamental to brain health. If you don’t feel like you matter, your neurochemistry changesโdopamine drops, motivation declines, and even your cognitive function can suffer.”
dr. scott sherr
And in case you didnโt already know it, John R. Miles (@John_R_Miles) takes your comments and questions for Momentum Friday right here every week! If you want him to answer your question, register your feedback, or tell your story on one of our upcoming weekly Momentum Friday episodes, drop us a line at [email protected]. Now, letโs dive in!
Listen to the episode on Apple Podcasts, Spotify, Podcast Addict, Pocket Casts, Stitcher, Castbox, Google Podcasts, Listen Notes, Amazon Music, or on your favorite podcast platform. You can watch the interview on YouTube below.
How GABA Impacts Your Brain: Dr. Scott Sherr on Stress, Sleep, and Cognitive Health
GABA (Gamma-Aminobutyric Acid) is often overlooked, yet it plays a fundamental role in maintaining balance in the brain. In this episode, Dr. Scott Sherr unpacks the science behind GABA and why it’s essential for reducing stress, improving sleep, and supporting overall mental health. He explores the intricate relationship between GABA and neurotransmitters like glutamine, the impact of alcohol on GABA receptors, and how breathwork can be a powerful tool for optimizing GABA levels.
Dr. Sherr also shares insights into nootropics, methylene blue, and other cutting-edge strategies to enhance brain function and longevity. Whether you’re looking to sharpen your focus, regulate your mood, or optimize your brainโs performance, this conversation offers science-backed strategies to help you take control of your cognitive health.
What Youโll Learn in This Episode:
- Understanding GABA โ The overlooked neurotransmitter essential for stress reduction, sleep, and cognitive balance.
- Methylene Blue and Brain Health โ A mitochondrial enhancer that boosts energy, mood, and neuroprotection.
- Nootropics for Cognitive Performance โ How smart drugs optimize memory, focus, and mental clarity.
- GABA and Mental Health โ Low GABA levels contribute to anxiety, depression, and suicidal ideation.
- Lifestyle and Nutrition for GABA โ Foods, vitamins, and stress management strategies to boost GABA naturally.
- Exercise, Breathwork, and Sleep โ Key habits to regulate GABA and enhance brain resilience.
- Alcohol, Benzos, and GABA Disruption โ The hidden dangers of substances that manipulate GABA function.
- AI and Personalized Medicine โ The future of brain health through tech-driven diagnostics and treatments.
WHY IS THIS EPISODE A MUST-LISTEN?
If you want to optimize your brain function, manage stress, and improve your mental health, this episode is packed with game-changing insights. Dr. Scott Sherr breaks down the critical role of GABA in emotional stability, sleep, and cognitive performanceโan aspect of brain health that is often overlooked.
You’ll learn how lifestyle choices, nutrition, and breathwork can naturally enhance GABA levels, as well as the risks of alcohol and benzodiazepines on neurotransmitter balance. Plus, Dr. Sherr dives into the cutting-edge science of nootropics, methylene blue, and the future of AI-driven health optimization. Whether you’re looking to enhance focus, prevent neurodegeneration, or simply feel better, this conversation is a must-hear!
PLEASE SCROLL DOWN FOR FEATURED RESOURCES
Thank You, BIOptimizers, For Sponsoring
This November, BIOptimizers is offering an exclusive Black Friday BLOWOUT! Get discounts on all their amazing productsโincluding Magnesium Breakthroughโplus up to $100 in free gifts. Donโt miss out! Visit https://bioptimizers.com/passion to shop now
Thank You, Hims, For Sponsoring
Hims: Regrow your hair before itโs too late! Start your free online visit today at Hims.com/PASSIONSTRUCK.
Thank You, Mint Mobile, For Sponsoring
Cut your wireless bill to 15 bucks a month at โMINT MOBILE dot com slash PASSION.โ
Thank You, Rosetta Stone, For Sponsoring
Unlock 25 languages for life at โROSETTASTONE.com/passionstruck.โ
Thank You, Prolon, For Sponsoring
Reset your health with 15% off at โProlonLife.com/passionstruck.โ
STARTER PACKS

Are you new to the show? These Starter Packs are collections of our most popular episodes grouped by topic, and we now have them on Spotify.
You can also browse starter packs for existing listeners to find your old favorites. Every week, John interviews everyday heroes from all walks of life. Learn how to subscribe to the show and never miss a new episode and topic.
Like this? Please subscribe and join me on my new YouTube platform for peak performance, life coaching, and personal mastery.
The Science Behind GABA and Its Role in Mental Health
GABA (Gamma-Aminobutyric Acid) is the brainโs primary inhibitory neurotransmitter, responsible for slowing down nerve signals and promoting relaxation. While dopamine, serotonin, and norepinephrine often dominate discussions on mental health, GABA plays a critical yet underappreciated role in emotional stability, sleep, and cognitive function.
A deficiency in GABA can manifest in various ways, including anxiety, restlessness, irritability, depression, and insomnia. In fact, research suggests that individuals with anxiety disorders or PTSD often have lower GABA levels, making it harder for them to regulate stress and intrusive thoughts. The overabundance of excitatory neurotransmitters like glutamate without sufficient GABA to balance them out can lead to hyperactivity, racing thoughts, and poor emotional control.
Enhancing GABA naturally involves several lifestyle and dietary interventions. Foods rich in glutamineโthe precursor to GABAโinclude leafy greens, fermented foods, whole grains, nuts, and lean meats. Additionally, magnesium and vitamin B6 play a crucial role in facilitating the conversion of glutamate into GABA, making supplementation a viable strategy for those struggling with stress and anxiety.
Beyond diet, certain practices can boost GABA activity. Breathwork techniques like box breathing (inhale for four seconds, hold for four, exhale for four) can activate the parasympathetic nervous system, promoting relaxation. Regular physical activity has also been shown to upregulate GABA receptors, while mindfulness meditation helps balance neural activity and reduce excitotoxicity in the brain.
For individuals needing additional support, nootropic compounds such as kava, L-theanine, and certain adaptogens enhance GABA function without the dependency risks associated with pharmaceutical interventions like benzodiazepines. However, supplementation should be integrated with lifestyle modifications for sustainable results.
The implications of GABA optimization extend beyond stress relief. Improved GABA function is linked to better sleep quality, enhanced focus, and emotional resilience. As Dr. Sherr explains, prioritizing GABA balance is crucial in todayโs fast-paced world, where chronic stress depletes neurotransmitter reserves, leaving individuals feeling wired yet fatigued. Understanding and supporting GABA activity is an essential piece of the puzzle in achieving optimal mental and physical well-being.
THANKS, SCOTT SHERR
If you enjoyed this interview with Scott Sherr, let him know by clicking on the link below and sending him a quick shout on Instagram:
Click here to show Scott Sherr your thoughts about todayโs episode on Instagram
Click here to let John R. Miles know about your number one takeaway from this episode!
If you want us to answer your questions or you want John to discuss a topic on one of our upcoming Momentum Friday episodes, drop us a line at [email protected].
RESOURCES FROM THE SHOW WITH DR. SHERR
Please note that some of the links on this page (books, movies, music, etc.) lead to affiliate programs for which The Passion Struck podcast receives compensation. Itโs just one of the ways we keep the lights on around here. Thank you so much for being so supportive!
- Dr. Sherr’s Website
- Integrative Hyperbaric Medicine and Health Optimization’s Website
- Nonprofit’s HOMe/HOPe Website
- Dr. Sherr’s Twitter
- Dr. Sherr’s Instagram
- Passion Struck Core Value System: https://passionstruck.com/the-passion-struck-core-belief-system/
- Listen to Passion Struckโs interviews with New York Times bestselling authors Gretchen Rubin and Seth Godin.
- Check out Passion Struckโs Episode Starter Packs on Spotify or Passion Struck starter packs to get started with the podcast.
My solo episode on The Science of Healthy Habits
My episode with Dr. Sherr on How to Improve Brain Function with Methylene Blue and Nootropics
Can’t miss my episode with Dr. Mark Hyman on the Secrets to Living Young Forever
Catch my interview with Dr. Lucia Aronica on the Impact of Personalized Nutrition on Epigenetics
Listen to my solo episode on Why Your Micro Choices Determine Your Life
About Todayโs Guest, Dr. Scott Sherr

Dr. Scott Sherr is a leading expert in health optimization and integrative medicine, specializing in hyperbaric oxygen therapy (HBOT), nootropics, and metabolic health. He is the founder of Health Optimization Medicine (HOMe) and serves as the Chief Operating Officer of Troscriptionsยฎ, a company dedicated to precision-dosed nootropics designed to enhance cognitive function and mental clarity.
With a background in internal medicine and a deep focus on cutting-edge wellness strategies, Dr. Sherr helps individuals optimize their brain and body by balancing neurotransmitters, improving mitochondrial function, and integrating personalized health solutions. His expertise spans areas such as the role of GABA in mental health, the impact of methylene blue on brain performance, and the future of AI-driven personalized medicine.
Through his work, Dr. Sherr bridges the gap between traditional medicine and advanced health optimization, empowering people to take control of their well-being and unlock their full potential.
Follow John R. Miles On Social
* Twitter: https://twitter.com/Milesjohnr
* Facebook: https://www.facebook.com/johnrmiles.c0m
* Medium: https://medium.com/@JohnRMilesโ
* Instagram: https://www.instagram.com/john_r_milesacks for existing listeners to find your old favorites. Every week, John interviews everyday heroes from all walks of life. Learn how to subscribe to the show and never miss a new episode and topic.
* Gear: https://www.zazzle.com/store/passion_struck/
Learn more about me: https://johnrmiles.com.
Passion Struck aspires to speak to the humanity of people in a way that makes them want to better, live better, and impact the world.
Passion Struckโs mission is to unlock the power of intentionality for the benefit of us all. To create a world where we live better, be better, and impact the world through our unique and powerful content.