New release - PASSION STRUCK


Dr. Dominic D’Agostino on Ketogenic Diets, Ketosis, and Optimizing Metabolic Health

Dr. Dominic D’Agostino is an expert on a wide range of topics related to ketogenic diets, ketosis, metabolic health, and how to thwart chronic conditions with diet and lifestyle.

Dominic D’Agostino is one of the world’s leading experts on ketogenic diets, studying its effects under the severe conditions of space and undersea. Additionally, Dr. D’Agostino has personally practiced the ketogenic diet for over a decade. In doing so, he brings substantial valuable personal experience along with his human and animal research. He also works with NASA and the Department of Defense, studying how the body performs in extreme environments.

No other diet (other than ketogenic diets) is defined by the elevation of a biomarker. So this makes it very interesting scientifically because you can precisely adjust the macronutrient ratios, and fat protein carbohydrates, to achieve a certain level of ketosis.

John R. Miles

Hear the secrets and philosophy of the World’s GREATEST high achievers every Monday and Thursday, and tune in each week for an inspirational Momentum Friday solo message.

Like this show? Please leave us a review here – even one sentence helps! Post a screenshot of you listening on Instagram & tag us to thank you personally!

Listen to the episode on Apple PodcastsSpotifyPodcast Addict, Pocket CastsStitcherCastboxGoogle PodcastsListen NotesAmazon Music, or on your favorite podcast platform. You can watch the interview on YouTube below.


What I Discuss With Dr. Dominic D’Agostino About Ketogenic Diets, Ketosis, and Metabolic Health

It’s been a hundred years since the ketogenic diet was developed, and yet we are still discovering its many benefits, including its positive effects on the epigenome. How fascinating is that? In this episode of the Passion Struck podcast Dr. D’Agostino and I discuss the therapeutic uses of the keto diet, including emerging applications in cancer and other chronic conditions, the impact of ketone supplements, studying its effects in extreme conditions, and much more. It is an episode packed with the latest research on ketosis and metabolic health – you wouldn’t want to miss it!

  • NASA’s Extreme Environment Mission Operations
  • How extreme environments impact the body
  • Hyperbaric Biomedical Research Laboratory at the University of South Florida
  • Negative effects of high-pressure oxygen
  • The basics of ketosis and the ketogenic diet
  • Benefits of Exogenous Ketones
  • Ketone Biomarker For Burning Fat
  • How the ketogenic diet hacks biomarkers
  • Metabolic health reduces depression and anxiety
  • Ketogenic diets can reduce midlife mortality
  • The keys to proper intermittent fasting
  • Difference between ketogenic diets, ketone esters, and ketone supplements
  • Reducing Inflammation
  • Why magnesium is underrated as a supplement
  • Ketones’ impact on epigenetic function
  • The sweet spot for how much we eat
  • Ketosis and alcohol – can you drink it?
  • Have any questions, comments, or stories you’d like to share? Drop us a line at [email protected]m!
  • And much more…
182 | Ketogenic Diets, Ketosis, and Metabolic Health | Dr. Dominic D’Agostino | Passion Struck with John R. Miles
182 | Ketogenic Diets, Ketosis, and Metabolic Health | Dr. Dominic D’Agostino | Passion Struck with John R. Miles

Thank You To Our Sponsors: More Info At PassionStruck.Com/Deals.

Our Patreon Page:

Thank You, Dry Farm Wines, For Sponsoring

This episode of Passion Struck with John R. Miles is brought to you by Dry Farm Wines, which Have No Chemical Additives for Aroma, Color, Flavor, or Texture Enhancement. Dry Farm Wines – The Only Natural Wine Club That Goes Above and Beyond Industry Standards. For Passion Struck listeners: Dry Farm Wines is offering an extra bottle in your first box for a penny (because it’s alcohol, it can’t be free). See all the details and collect your wine at

Starter Packs

New to the show? These Starter Packs are collections of our most popular episodes grouped by topic, and we now have them also on Spotify. You can also browse starter packs for existing listeners to find your old favorites. Every week, John interviews everyday heroes from all walks of life. Learn how to subscribe to the show and never miss a new episode and topic.

Like this? Please subscribe, and join me on my new YouTube platform for peak performance, life coaching, and personal growth:

More From My Interview With Dr. Dominic D’Agostino.

During our interview, I asked Dom to discuss how ketogenic diets can reduce midlife mortality.

Dr. Dominic D’Agostino explains, “I think the ketogenic diet and under the umbrella of that would just be a low carb diet. So ketogenic diets are a rather extreme diet in that it limits carbohydrates so low that you would actually eliminate a lot of foods that are good for you, like fruits and vegetables, which even need to be limited to some extent, with a ketogenic diet.

But you could simply get many benefits from a ketogenic diet by reducing total carbohydrate consumption. A good area to start would be under 100 grams a day. I would say most people can do that pretty easily. And that would be more like a higher high to a moderate protein diet, moderate fat diet, and low carbohydrate diet, and then start with that, and then see how you feel. And then, over time, your insulin level will decrease, your glucose variability will be reduced, and most people will probably have a decrease in energy in the beginning.

But after your body adapts to a lower glucose setpoint, then you start burning fat more efficiently. So the real adaptations start to happen after a week, so the second week and third week, and by four to six weeks, your body is burning considerably more fat for energy. And we can even measure this like in the lab with a metabolic cart and look at something called the respiratory quotient. The respiratory quotient goes down and shows that you’re burning more fat for energy than carbohydrates.

Quote by Dominic D'Agostino for the Passion Struck Podcast: If someone wants to enhance the ketogenic state further, they could actually take exogenous ketones, which would help promote the ketogenic state in the body.

Your mood will start improving as metabolic biomarkers improve and your body composition improves. So this is dependent to some extent on what we call insulin sensitivity. And markers. For me, my HCRSP, which has high sensitivity C reactive protein, fluctuated between one and two. And since I’ve been on a low-carb ketogenic diet, it’s 0.1 or 0.2. Or what is non-detectable, can’t even measure it. So my inflammation went way down, my joints felt better the brain fog went away.

But I would like to emphasize for people that if they start on a low carb diet, get their body adapted to a low carb diet, and then maybe experiment with a ketogenic diet, where you drop the carbohydrates so low that you’re really then burning fat. And for overweight people, that is the fastest way to lose fat with a ketogenic diet.

One way to speed up progress is to do what’s called intermittent fasting. In science, we call this time-restricted feeding. That’s like the scientific name for it, where you could have breakfast and then stop eating your last meal at like 6 pm. Right, and then not eat again, until like nine or 10 pm, the next day.

That fasting window will actually put your body into a state of mild ketosis. And what I like to do is actually a couple of days a week if I don’t have my first meal until 12 noon or 2 pm. And those days that I do intermittent fasting, I am most productive in the mornings. I have the clearest thinking I had the most energy, and believe it or not, in the beginning, you might feel hungry, but the more you do it, the easier it gets.

And then, over time, you’ll derive more benefits from this pattern. And there’s a ton of research on intermittent fasting by Sachin Panda. He was a speaker at our metabolic health summit, a conference we hold in many speakers on these topics. There’s a lot of data on intermittent fasting and time-restricted feeding. And it tends to augment the ketogenic diet further and makes it easier to follow over time.

Thanks, Dominic D’Agostiono!

If you enjoyed this interview with Dominic D’Agostino, let him know by clicking on the link below and sending him a quick shout on Instagram or Twitter:

Click here to thank Dominic D’Agostino on Instagram!

Click here to thank Dominic D’Agostino on Twitter!

Click here to let John R. Miles know about your number one takeaway from this episode!

And if you want us to answer your questions or you have a topic you would like John to discuss on one of our upcoming weekly Momentum Friday episodes, drop us a line at [email protected].

Resources From The Show With Dr. Dominic D’Agostino

Please note that some of the links on this page (books, movies, music, etc.) lead to affiliate programs for which The Passion Struck podcast receives compensation. It’s just one of the ways we keep the lights on around here. Thank you so much for being so supportive!

* Website:

* Instagram: 

* Facebook: 

* Twitter: 

Show Links

* Norwitz, N. G., Winwood, R., Stubbs, B. J., D’Agostino, D. P., & Barnes, P. J. (2021). Case Report: Ketogenic Diet Is Associated With Improvements in Chronic
Obstructive Pulmonary Disease. Front. Med., 29 July 2021 |

* Gambardella I, Ascione G, D’Agostino DP, Ari C, Ivascu N, Villena-Vargas J, Girardi L. Neuroprotection of Ketosis in Acute Injury of the Mammalian Central
Nervous System: a Meta-Analysis. J Neurochem. 2021; 00: 1– 14. PMID: 33675563.

* Ari C, D’Agostino DP, Bharwani S, Rehsi A, Moss S, Schmer-Galunder S, Fiore S. Changes in Motor Function in Response to Living in an Extreme Underwater Saturation
Environment under High Stress and Increased Workload. FASEB. 20 April 2020

* My solo episode on why loneliness is killing us and 9 ways to overcome it:

* My interview with Ari Wallach on the Longpath Mindset and creating a future with something greater than yourself in mind:

* My interview with Dr. Ayelet Fishbach on how you get things done through the science of motivation: 

* My interview with Dr. Katy Milkman on the behavior science behind how we change: 

* My interview with Jeff Walker on how you create systems change to solve world-centric issues:

* My interview with Jean Oelwang on the power of partnerships in solving novel issues that impact society:

* My solo episode on why micro choices matter:

* My solo episode on why you must feel to heal:

About Today’s Guest Dr. Dominic D’Agostino

Passion Struck with John R. Miles album cover episode 182 with Dr. Dominic D'Agostino on the ketogenic diet

Dominic D’Agostino, Ph.D., is a tenured Associate Professor in the Department of Molecular
Pharmacology and Physiology at the University of South Florida (USF) Morsani College of Medicine and a
Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. D’Agostino received his
B.S. in Nutritional Science and Biological Sciences in 1998 at Rutgers University before receiving a
Predoctoral Fellowship in neuroscience at the University of Medicine and Dentistry of New Jersey.

In 2004 Dr. D’Agostino entered into a postdoctoral fellowship in neuroscience at the Boonshoft
School of Medicine at Wright State University in Ohio before moving his research program to USF Tampa
in 2006.

Funding through the Department of Defense (DoD) and Office of Naval Research (ONR) lead
him to develop and patent unique technologies for a wide range of applications related to enhancing
resilience in undersea environments, treating neurological disorders, and in treatment and prevention of
metabolic-based diseases. Dr. D’Agostino continues to work closely with federal organizations, private
industry, 501c3 foundations, and media outlets.

Follow John R. Miles On The Socials

* Twitter:

* Facebook:

* Medium:​

* Instagram:

* LinkedIn:

* Blog:

* Instagram:

* Gear:

John R. Miles is a serial entrepreneur and the CEO and founder of Passion Struck. This full-service media company helps people live intentionally by creating best-in-class educational and entertainment content. John is also a prolific public speaker, venture capitalist, and author named to the ComputerWorld Top 100 IT Leaders.

John is the host of the PassionStruckPodcast. The show focused on exploring the mindset and philosophy of the world’s most inspiring people to learn their lessons to living intentionally. Passion Struck aspires to speak to the humanity of people in a way that makes them want to live better, be better and impact.

Stay tuned for JJohn’slatest project, his upcoming book, which will be published in summer 2022.

Learn more about me:

Download the 5 Simple Steps to Find Your Passion
Scroll to Top