Dr. Nicole Cain knows what it feels like to live in the grip of anxiety. As both a naturopathic doctor and clinical psychologist, she has spent years helping people who feel trapped in cycles of panic, fear, and emotional overwhelm. Her new book, Panic Proof: The New Holistic Solution to End Your Anxiety Forever, takes a fresh approach: instead of treating anxiety as something to be suppressed, she shows us how to understand it as the bodyโs way of signaling deeper needs.
In our conversation, Nicole shares how her own journey through a personal crisis reshaped the way she thinks about mental health. We explore her framework of nine unique anxiety types, the powerful connection between the gut and the brain, and why your body often sends messages long before your conscious mind catches up. Along the way, she offers a simple three-minute practice to help you calm your nervous system, regain clarity, and begin healing from the inside out.
This episode isnโt about erasing anxiety โ itโs about learning to listen to it, work with it, and ultimately become panic proof.
The Nervous System and Why Logic Isnโt Enough

We like to believe we can think our way out of anxiety. But the nervous system often has other plans. Dr. Cain explains that our brains evolved for survival, not happiness. When your salience network (primarily the anterior insula and anterior cingulate) flags something as โpossibly important,โ it routes that signal to fast threat systems. The amygdala and HPA axis mobilize the body, heart rate rises, breathing shortens, muscles brace, before the slower, reflective networks (prefrontal cortex) can fully weigh in. In that state, your โlogic centerโ is partially offline. Itโs like trying to run a board meeting during a fire drill.
Thatโs why simply telling yourself โIโm fineโ doesnโt calm the storm. To feel safe, you need bottom-up practices that convince the body it is no longer in danger.
Whatโs actually happening in a spike
- Low road, then high road: A rapid, subcortical threat pathway acts first; the thoughtful, cortical pathway catches up later.
- State gates story: Physiological arousal narrows attention and pushes catastrophic predictions. In other words, your state shapes your story.
- Polyvagal framing: When the nervous system shifts out of โventral vagalโ (safe/social) into sympathetic fight/flightโor further into shutdownโcognition becomes rigid and literal. Conversation helps only after the state softens.
Nine Anxiety Types: One Size Doesnโt Fit All
One of the most practical contributions of Dr. Cainโs book Panic Proof is her framework of nine anxiety types. Instead of lumping every struggle into โgeneralized anxiety,โ she maps distinct patterns: thought anxiety, chest anxiety, gut anxiety, nervous system anxiety, endocrine anxiety, immune system anxiety, depression-anxiety, anger-anxiety, and trauma-anxiety.
Why does this matter? Because different patterns respond to different tools. Talk therapy wonโt stop reflux. Antidepressants wonโt correct a thyroid imbalance. Precision matters. When you know your type, you can target interventions that actually work.
The GutโBrain Connection and the Rise of Psychobiotics
A surprising amount of anxiety begins in the gut. Our modern diets and overuse of antibiotics often create dysbiosisโimbalances that inflame the body and cloud the brain. Dr. Cain highlights the emerging science of psychobiotics: probiotic strains that directly influence mood and stress responses by producing neurotransmitters like GABA.
The simple takeaway: your gut health is mental health. And the easiest place to start is fiberโfeeding the good bacteria that keep your system resilient.
Trauma, Timekeeping, and the โStuck Pastโ
One of the most powerful parts of the conversation is Dr. Cainโs metaphor of the Timekeeper. After trauma, the brain can get stuck timestamping past danger as if itโs happening in the present. Thatโs why a smell, sound, or image can trigger panic even when you know youโre safe.
Healing requires helping the nervous system reset its clock. Dr. Cain describes a three-minute hack for bringing those old memories into the present so they lose their grip, and she emphasizes the importance of trauma-informed modalities like EMDR.
โMedicine is obsessed with getting rid of symptoms, but that doesnโt mean the problem is gone. It will often just show up somewhere else.โ
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DR. Nicole cain
Building a Panic-Proof Plan
So, how do you apply all of this? Dr. Cain outlines a practical blueprint that begins with awareness and builds toward integration:
- Notice the whispers. Catch the first signs your system is leaving the โgreen zone.โ
- Stabilize your baseline. Sleep, nutrition, and simple vagal-toning practices calm the background noise.
- Match tools to type. Gut anxiety? Support digestion. Thought anxiety? Use grounding practices that bring logic back online.
- Reset the Timekeeper. Trauma-informed work clears old danger loops.
- Integrate gradually. Pair exposures with calming skills so progress compounds without overwhelm.
The goal isnโt to erase anxiety completely. Itโs to reclaim agencyโto know you can meet symptoms with clarity instead of fear.
Quick Wins to Try Today

- Protect a nightly wind-down by cutting caffeine after noon and screens before bed.
- Practice six slow breaths per minute for five minutes.
- Step outside for morning light before looking at a screen.
- Add one serving of fiber-rich foods to your day.
- Name what youโre feeling: โAnxiety is here. My body is protecting me.โ
Why this conversation matters
Anxiety steals timeโhours lost to panic attacks, days lost to avoidance. Dr. Nicole Cainโs approach gives that time back by treating the body, the brain, and the story together. When your nervous system feels safe, your mind can focus, your values can lead, and your life can open again.
RESOURCES FROM THE SHOW WITH DR. NICOLE CAIN
Please note that some of the links on this page (books, movies, music, etc.) lead to affiliate programs for which The Passion Struck podcast receives compensation. Itโs just one of the ways we keep the lights on around here. Thank you so much for being so supportive!
- Dr. Nicole Cain’s Website
- Nicole Cain’s Instagram
- Nicole Cain’s Facebook
- BUY Dr. Nicole Cain’s Book, โPanic Proofโ
- Which Of The 9 Types Of Anxiety Do You Experience? Take Dr. Cain’s Quiz and find out!
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- *Apparel with a message: StartMattering.com โ โYou Matter. Live Like It.โ
- Learn more about me: https://johnrmiles.com.
About Todayโs Guest, Dr. Nicole Cain

Dr. Nicole Cain is a licensed naturopathic doctor and clinical psychologist specializing in integrative approaches to anxiety, trauma, and emotional health. With a unique background that bridges natural medicine and clinical psychology, she blends modern science with holistic modalities to help people heal at the rootโaddressing the mind, body, and spirit as one interconnected system.
Dr. Cain is the author of Panic Proof: The New Holistic Solution to End Your Anxiety Forever and a recognized expert in psychobiotics, botanical medicine, and evidence-based psychotherapy. Through her clinical work, podcast appearances, and educational resources, she empowers individuals to overcome panic, anxiety, and emotional overwhelm so they can step into a life of greater resilience, peace, and purpose.
Next Steps
To learn more about Dr. Nicole Cain, visit drnicolecain.com, connect with her on Instagram, or pick up her book Panic Proof: Managing Your Mental HealthโSo They Donโt Manage You.
You can listen to this episode on Apple Podcasts, Spotify, Amazon Music, Google Podcasts, or YouTube. Donโt forget to explore our Passion Struck Starter Packs on Spotify for curated playlists that will help you dive deeper into topics like anxiety relief, resilience, and mental health mastery.
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